The Synchronized swimming competition at the 2010 Central American and Caribbean Games was held in Mayagüez, Puerto Rico.
The tournament was scheduled to be held from 25–31 July at the Natatorio RUM in Mayagüez.
| Event | Gold | Silver | Bronze |
|---|---|---|---|
| Solo Technical Routine | Nuria Diosdado (MEX) | Asly Alegria (COL) | Greisi Gomez (VEN) |
| Duet Technical Routine | Mexico | Colombia | Venezuela |
| Team Technical Routine | Mexico | Colombia | Venezuela |
| Solo Free Routine | Mexico | Venezuela | Colombia |
| Duet Free Routine | Mexico | Venezuela | Colombia |
| Team Free Routine | Mexico | Colombia | Venezuela |
| Combination | Mexico | Colombia | Venezuela |
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